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Target intelligence / Profile preview
SARS-CoV-2 Spike S1 Receptor Binding Domain (SARS-CoV-2 Spike S1 RBD)
- Target
- SARS-CoV-2 Spike S1 RBD
- Molecular classification
- Viral protein, Glycoprotein, Receptor Ligand
01
Overview
The SARS-CoV-2 Spike S1 Receptor Binding Domain (RBD) is a critical component of the viral spike protein responsible for binding to the human ACE2 receptor. This interaction mediates viral attachment and entry into host cells, initiating the infection process. As such, it is a key target for vaccine and therapeutic development. The RBD undergoes conformational changes to expose its ACE2 binding site and is subject to glycosylation and proteolytic processing. Its sequence also varies between SARS-CoV-2 variants of concern, which affects binding affinity to ACE2 and antibody neutralization.
- Other names
- SARS-CoV-2 Spike RBDSpike S1 RBDS1 Receptor Binding DomainRBDSpike protein Receptor Binding Domain
02
Mechanism of action
Binding to ACE2 receptor to block viral entry; antibody neutralization of RBD to prevent ACE2 binding; disruption of ACE2-RBD interaction
03
Biological functions
Receptor bindingViral attachmentHost cell entryInitiation of infection
04
Disease associations
InfectionCOVID-19 pathogenesis
05
Safety considerations
Potential for antibody-dependent enhancement (ADE)Evasion by viral mutations
06
Interacting drugs
Neutralizing antibodies
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