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Target intelligence / Profile preview
SARS-CoV-2 Virus Particle (SARS-CoV-2)
- Target
- SARS-CoV-2
- Molecular classification
- Virus, RNA Virus, Coronavirus
01
Overview
SARS-CoV-2 is the causative agent of COVID-19 and belongs to the coronavirus family. It is an enveloped, positive-sense single-stranded RNA virus with a spherical shape and a diameter ranging from 60 to 140 nanometers. The virion surface is characterized by prominent spike (S) proteins that give it a crown-like appearance under electron microscopy. Its infection process begins when the spike protein binds ACE2 on target cells and enters by membrane fusion.
- Other names
- COVID-19 VirusSevere Acute Respiratory Syndrome Coronavirus 2
02
Mechanism of action
Various, including inhibition of viral RNA polymerase, protease inhibition, and neutralization of the spike protein.
03
Biological functions
InfectionReplicationHost Cell EntryImmune Evasion
04
Disease associations
COVID-19PneumoniaAcute Respiratory Distress Syndrome (ARDS)
05
Safety considerations
Viral resistanceImmune escapePotential for long-term health effects
06
Interacting drugs
Remdesivir
3 more in the full profile.
07
Biomarkers
Viral load (RT-PCR)Antibody titersPresence of viral RNA in respiratory samples
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