SAT1 divergent transcript (SAT1-DT)

SAT1 divergent transcript (SAT1-DT; also known as lnc-ACOT9-1) is a human long non-coding RNA gene located between and divergently transcribed from the SAT1 and ACOT9 protein-coding loci[5][7]. It has been shown to be consistently and significantly upregulated in juvenile myelomonocytic leukemia (JMML), across different mutational subtypes of this disease, suggesting a role in pathogenesis or maintenance of malignant states[7]. Long non-coding RNAs like SAT1-DT are increasingly recognized as important regulators of gene expression, acting through modulation of transcription, chromatin architecture, or RNA processing in either *cis* (locally) or *trans* (distally)[2][4]. Although its precise molecular mechanism remains to be clarified, SAT1-DT is considered a candidate therapeutic target and potential biomarker for JMML.

Other names

lnc-ACOT9-1SAT1-DT

Not yet elucidated for specific drugs; general lncRNA mechanisms include *cis*- or *trans*-regulation of adjacent gene expression, chromatin modification, and transcriptional modulation