SATB2 antisense RNA 1 (non-protein coding) (SATB2-AS1)

SATB2 antisense RNA 1 (SATB2-AS1) is a long non-coding RNA predominantly expressed in colorectal tissue, and also present in brain tissue. It is typically downregulated in colorectal cancer and glioma compared to healthy tissue. SATB2-AS1 regulates the expression of the SATB2 gene (Special AT-rich binding protein 2) by acting as a scaffold for chromatin-modifying proteins, promoting histone modification and DNA demethylation at the SATB2 promoter. Functionally, SATB2-AS1 inhibits tumor cell metastasis, modulates immune cell infiltration and immune gene expression, inhibits glycolysis, suppresses cell proliferation, and promotes apoptosis in cancer cells. In glioma, it also acts as a microRNA sponge, particularly for miR-671-5p, modulating downstream gene expression. Reduced SATB2-AS1 expression is linked to more aggressive disease and poorer prognosis in both colorectal cancer and glioma, suggesting its role as a tumor suppressor and a potential prognostic biomarker[1][3][4].

Other names

SATB2-AS1SATB2 antisense RNA 1SATB2 antisense RNA 1 (non-protein coding)

Acts as a molecular scaffold, recruiting chromatin-modulating proteins (WDR5 and GADD45A) to promote histone H3K4 methylation and DNA demethylation at the SATB2 promoter, thus activating SATB2 transcription (in cis) in colorectal cancer. Functions as a microRNA sponge (notably for miR-671-5p), thereby regulating targets such as CDR1 and VSNL1 in glioma.