Scavenger receptor class B member 2 (SCARB2)

Scavenger receptor class B member 2 (SCARB2), also known as Lysosomal integral membrane protein 2 (LIMP-2, or LGP85, CD36b like-2), is a highly glycosylated lysosomal membrane protein of 478 amino acids and a member of the CD36 family[1][3][6]. It is essential for the transport of beta-glucocerebrosidase from the endoplasmic reticulum to lysosomes, where it maintains lysosomal structure and function[3][6]. SCARB2 also transiently shuttles to the plasma membrane and serves as the entry receptor for certain picornaviruses, notably enterovirus 71 and some coxsackieviruses[1][3]. Mutations in the SCARB2 gene are associated with lysosomal storage disorders, particularly action myoclonus–renal failure syndrome (AMRF), which combines neurological and renal symptoms[1][3]. SCARB2 is widely expressed in tissues including the brain, heart, liver, and macrophages[5][3]. Besides lysosomal cell biology, its surface expression can make cells susceptible to viral infection, and SCARB2 dysfunction has implications for neurodegenerative and infectious diseases[1][3][5][6].

Other names

Lysosomal integral membrane protein 2 (LIMP-2)Lysosomal glycoprotein 85 (LGP85)CD36b like-2

As a viral receptor: mediates viral entry for certain enteroviruses by binding and promoting endocytosis. As a lysosomal transporter: mediates lysosomal trafficking of beta-glucocerebrosidase by facilitating its delivery and membrane fusion.