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Target intelligence / Profile preview
Scavenger Receptor Class B Type 1 (SR-BI)
- Target
- SR-BI
- Molecular classification
- Scavenger receptor, Membrane protein, Receptor
01
Overview
Scavenger receptor class B type 1 (SR-BI) is an integral membrane protein that functions primarily as a receptor for high-density lipoprotein (HDL), playing a central role in cholesterol homeostasis, reverse cholesterol transport, steroidogenesis, and immune response. It is expressed in the liver, steroidogenic tissues, enterocytes, endothelial cells, macrophages, dendritic cells, and astrocytes, and its activity influences the risk of cardiovascular disease, Alzheimer's disease, and immune dysregulation.
- Other names
- SRB1SCARB1
02
Mechanism of action
Modulation of HDL cholesterol uptake and reverse cholesterol transport; modulation of immune response
03
Biological functions
Cholesterol homeostasisReverse cholesterol transportLipoprotein metabolismSteroidogenesisVitamin uptakeImmune responseHDL-mediated cholesterol trafficking
04
Disease associations
AtherosclerosisCardiovascular diseaseAlzheimer's DiseaseImmune dysregulation
05
Safety considerations
Potential for promoting LDL deposition when overexpressed on endotheliumParadoxical increase in CHD risk with certain variants despite increased HDL-C
06
Biomarkers
HDL-C levelsCarotid intima-media thickness
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