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Target intelligence / Profile preview
Scavenger Receptor Class B Type I (SR-BI)
- Target
- SR-BI
- Molecular classification
- Receptor, Scavenger Receptor
01
Overview
Scavenger Receptor Class B Type I (SR-BI) is a cell surface glycoprotein predominantly expressed in the liver and steroidogenic tissues. It plays a central role in HDL metabolism by mediating the selective uptake of cholesteryl esters from circulating HDL particles into hepatocytes. SR-BI facilitates the transfer of cholesteryl esters from HDL into liver cells without internalizing or degrading the entire particle, a process crucial for reverse cholesterol transport.
- Other names
- Hepatic HDL Uptake ReceptorSCARB1
02
Mechanism of action
Modulation of hepatic SR-BI activity to enhance cholesterol efflux and bile secretion.
03
Biological functions
Lipid transportCholesterol homeostasisReverse cholesterol transportHDL catabolismSelective cholesterol ester uptakeLipid hormone synthesis
04
Disease associations
Cardiovascular diseaseDyslipidemia
05
Safety considerations
Potential for unintended effects on steroid hormone synthesisOff-target effects due to broad tissue distribution
06
Biomarkers
HDL-cholesterol levelsSCARB1 expression levels
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