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Target intelligence / Profile preview
Scavenger Receptor Cysteine-Rich Type 1 Protein M130 (CD163)
- Target
- CD163
- Molecular classification
- Scavenger Receptor Cysteine-Rich Superfamily, SRCR
01
Overview
Scavenger receptor cysteine-rich type 1 protein M130, commonly known as CD163, is an acute phase-regulated transmembrane protein primarily expressed on monocytes and macrophages. CD163 plays a crucial role in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages, thereby protecting tissues from free hemoglobin-mediated oxidative damage. Elevated levels of sCD163 are associated with various inflammatory diseases and serve as indicators of macrophage activation status.
- Other names
- Hemoglobin scavenger receptorM130
02
Mechanism of action
Endocytosis of Hemoglobin/Haptoglobin complexes
03
Biological functions
Clearance/endocytosis of Hb/Hp complexesProtection against oxidative damageIron recyclingImmune response
04
Disease associations
Cardiovascular diseaseAutoimmune disordersNeurological diseasesCancerInflammation
05
Biomarkers
sCD163
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