Scavenger receptors on myeloid cells (SRs)

Scavenger receptors on myeloid cells represent a structurally diverse family of cell surface proteins primarily expressed on macrophages, monocytes, and dendritic cells. These receptors, which include members such as Scavenger Receptor Class A Member 1 (MSR1/CD204), CD36, and SCARB1, are characterized by their ability to bind a broad spectrum of ligands, including modified lipoproteins (e.g., oxidized LDL), apoptotic cells, and various pathogens. They play a dual role in physiology: maintaining tissue homeostasis through the clearance of cellular debris and lipids, and serving as pattern recognition receptors that initiate innate immune responses. In disease states, these receptors are often dysregulated; for instance, they facilitate foam cell formation in atherosclerosis and contribute to the immunosuppressive environment of tumors by acting as "myeloid checkpoints." Consequently, they have emerged as attractive therapeutic targets, with strategies focusing on blocking their pro-inflammatory signaling or utilizing them for the targeted delivery of drugs to specific myeloid populations.

Other names

Myeloid scavenger receptorsMacrophage scavenger receptorsSRsPattern recognition scavenger receptors

Inhibition of ligand binding, Modulation of lipid flux, Reprogramming of tumor-associated macrophages, Enhancement of phagocytosis, Targeted drug delivery