Schistosoma mansoni fatty acid-binding protein (Sm14)

Schistosoma mansoni fatty acid-binding protein (Sm14) is a small (approximately 14 kDa) cytosolic protein crucial for the parasite's acquisition of fatty acids, which it cannot synthesize on its own, from the host[1][2][3][7]. Sm14 exemplifies a barrel-shaped β-pleated structure typical of FABPs, highly optimized to bind arachidonic acid and oleic acid[1][3][7]. The protein plays an essential role in lipid transport, membrane formation, and the synthesis of molecules that aid immune evasion, making it critical for parasite survival and pathogenesis[2][7]. Sm14 is a key vaccine target as immunization studies show strong, protective, Th1-type responses and cross-reactivity with related helminth species[4][8]. Its binding site structure and function have been well characterized, validating its role as a high-value therapeutic and diagnostic target in schistosomiasis research[1][3][4].

Other names

Sm14fatty acid-binding protein (FABP)Schistosoma mansoni FABP

Vaccines targeting Sm14 (induce Th1-mediated immune response protective against Schistosoma mansoni infection) Prevention of fatty acid uptake, potentially interfering with membrane formation and immune evasion