Schwann cell apoptosis

Schwann cell apoptosis is the programmed cell death of the primary glial cells in the peripheral nervous system (PNS), which are essential for myelinating axons and providing vital trophic support to neurons (PMID: 25163372). In pathological conditions such as diabetic neuropathy, leprosy, or traumatic nerve injury, these cells undergo apoptosis due to oxidative stress, hyperglycemia, or the loss of axonal contact (PMID: 15150174). The activation of specific death receptors, most notably the p75 neurotrophin receptor (p75NTR), is a primary molecular driver of this apoptotic process following injury (Journal of Neuroscience, 2004). Because the loss of Schwann cells leads to demyelination and subsequent axonal degeneration, preventing their death is a major therapeutic goal for preserving nerve function and promoting regeneration. Potential treatments under investigation include neurotrophic factors like Nerve Growth Factor (NGF) or antioxidants that mitigate the triggers of the apoptotic cascade to sustain the Schwann cell population (PMID: 16807217).

Other names

Schwann cell programmed cell deathPeripheral glial cell apoptosisSC apoptosis

Prevention of programmed cell death through the modulation of Bcl-2 family proteins, inhibition of executioner caspases, or activation of survival signaling pathways such as PI3K/Akt to maintain glial support for axons.