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Target intelligence / Profile preview
Scm polycomb group protein like 1 (SCML1)
- Target
- SCML1
- Molecular classification
- Other, Polycomb group protein, Transcription regulator
01
Overview
Scm polycomb group protein like 1 (SCML1) is a putative member of the Polycomb group (PcG) proteins, which are involved in forming multiprotein complexes to maintain the transcriptionally repressive state of target genes throughout development. It is predicted to enable chromatin and histone binding and functions as a transcriptional repressor, likely playing roles in germ cell nuclei, and may be involved in spermatogenesis. While deletion of the SCML1 locus can co-occur with developmental disorders, SCML1 itself is not currently considered a direct therapeutic or pharmacological target[1][8][9][11].
- Other names
- Sex comb on midleg-like protein 1SCML1sex comb on midleg like 1
02
Biological functions
Chromatin bindingHistone bindingNegative regulation of DNA-templated transcriptionPossibly involved in spermatogenesisTranscriptional repression
03
Disease associations
Developmental disorders (notably in X chromosome microdeletion syndromes such as Nance-Horan syndrome)Other
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