SCO-spondin pseudogene (SSPOP)

SCO-spondin, encoded by the SSPO gene, is a giant multidomain extracellular matrix glycoprotein secreted by the subcommissural organ in the brain during development, involved in axonal growth, Reissner’s fiber formation, and neuroepithelial differentiation[1][2][3][4][5]. However, SSPOP ("SCO-spondin, pseudogene") refers to a pseudogene related to SSPO, not a protein-coding gene with functional protein product[3][5][7]. Most sources refer to SSPOP as a pseudogene, which means it is not a direct molecular or therapeutic target and does not encode a functional protein product[3][5][7]. Functional and therapeutic information applies to the protein-coding SSPO gene, not to SSPOP. Key Points: - SSPOP is a pseudogene, a non-protein-coding genetic segment, so it is not considered a molecular target for drugs or known to have direct roles in disease, mechanism, drug interaction, or biomarker status[3][5][7]. - Information about biological function, disease implication, and potential as a therapeutic target would refer to SSPO (SCO-spondin), not to SSPOP (the pseudogene). Summary of Deviation/Correction: - The majority of functional information found is for SSPO, which encodes the SCO-spondin protein involved in neural development. SSPOP is a related pseudogene and does not produce protein or act as a therapeutic target[3][5][7]. - Therefore, "is_incorrect" is true for interpreting SSPOP as a molecular target in the therapeutic sense. For research about the actual protein, refer to "SCO-spondin" or the SSPO gene.

Other names

SCO-spondinKIAA2036SSPOKIAA0543FLJ36112subcommissural organ spondinSCO proteinthrombospondin domain containingSCO-spondin homolog (Bos taurus)