Scribble planar cell polarity protein (SCRIB)

Scribble planar cell polarity protein (SCRIB) is a multidomain scaffold protein encoded by the SCRIB gene in humans[1][5]. It is part of the LAP family (Leucine-rich repeat and PDZ domain proteins) and localizes mainly to the basolateral membrane of polarized epithelial cells, where it plays a critical role in establishing and maintaining cell polarity, regulating cell migration, cell proliferation, and morphogenesis in both epithelial and neuronal tissues[1][3][5]. SCRIB functions as a tumor suppressor and is essential for cell–cell adhesion and proper tissue architecture. Its loss or mislocalization is associated with loss of polarity, increased cell motility, disruption of cell junctions, and promotion of cancer progression, particularly via its involvement in epithelial-mesenchymal transition (EMT)[1][3][5]. SCRIB acts by forming complexes with other key regulators of cell junctions and polarity, such as DLGAP5 and LLGL1, and interacts with several proteins through its PDZ domains, including the cell adhesion receptor TMIGD1[3]. In addition, SCRIB is implicated in T-cell polarization and immune response regulation[5]. There are no known direct pharmacological modulators or drugs targeting SCRIB at present, and it is not conventionally regarded as a direct therapeutic target, but as a crucial molecule in pathways relevant to cancer biology[1][5]. Note: - SCRIB is not a receptor, enzyme, transporter, or classical drug target; it is a scaffold protein with essential regulatory roles in cell polarity and tumor suppression[1][3][5]. - No directly interacting drugs, mechanisms of action, or clinical biomarkers related to targeted therapy were found in the current literature[1][3][5].

Other names

Scribbleprotein scribble homologCRIB1KIAA0147LAP4SCRB1VARTULhScribSCRIB overlapping open reading frame protein (oSCRIB)scribbled homologSCRIBL