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SDA1 domain-containing protein 1 (SDAD1)
- Target
- SDAD1
- Molecular classification
- Other
01
Overview
SDA1 domain-containing protein 1 (SDAD1) is a human protein required for the export of 60S pre-ribosomal subunits from the nucleus to the cytoplasm[7][5][4]. It is involved in ribosomal large subunit biogenesis and nucleocytoplasmic transport of these subunits[4][7]. While SDAD1 does not fit classic therapeutic target classes such as receptors or enzymes, its expression has been implicated in colon cancer cell proliferation, migration, and invasion, making it of interest in oncology research[6]. No drugs are currently known to directly target SDAD1, and it is not typically used as a biomarker or known to present specific therapeutic safety concerns.
- Other names
- Protein SDA1 homologNUC130hSDAFLJ10498Sda1nucleolar protein 130SDA1 domain-containing protein 1
02
Biological functions
Ribosomal large subunit biogenesisRibosomal large subunit export from nucleus
03
Disease associations
Cancer (notable association in colon cancer)
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