SDCBP2 antisense RNA 1 (SDCBP2-AS1)

SDCBP2 antisense RNA 1 (SDCBP2-AS1) is a long non-coding RNA (lncRNA) gene that regulates various cellular processes including cell proliferation, migration, and apoptosis[1][2]. It functions primarily by interacting with proteins (such as hnRNP K and YBX1) and acting as a sponge for microRNAs, thereby influencing gene expression[1][2]. SDCBP2-AS1 has been shown to suppress tumorigenesis and metastasis in gastric cancer by destabilizing β-catenin and inhibiting oncogenic pathways[2]. Expression levels of SDCBP2-AS1 may serve as a prognostic marker in certain cancers such as gastric and ovarian cancer, and it is considered a potential target for therapeutic intervention, though no drugs currently directly target this molecule[2][1][3].

Other names

SDCBP2 antisense RNA 1 (non-protein coding)SDCBP2-AS1syndecan-binding protein 2 antisense RNA 1HGNC:44314NCBI Gene:100507495Ensembl:ENSG00000234684

Therapeutic modulation often proposed via RNA interference, antisense oligonucleotides, or targeted RNA delivery, but none directly approved or widely used