SDHB pseudogene 1 (SDHBP1)

SDHB pseudogene 1 (SDHBP1) is classified as a pseudogene related to the succinate dehydrogenase complex iron sulfur subunit B (SDHB) gene, which encodes a critical component of mitochondrial complex II in the respiratory chain[1][7][10]. Unlike the functional SDHB gene, SDHB pseudogene 1 does not code for a protein and lacks direct biological or clinical relevance. Because it is not expressed as a functional protein, it is not considered a therapeutic target, biomarker, or subject to drug interactions, and there is no evidence linking it directly to diseases or therapeutic strategies. The actual target relevant in disease (e.g., paraganglioma, pheochromocytoma, mitochondrial dysfunction, tumorigenesis) is the protein-coding gene SDHB, not its pseudogenes[1][3][6][7][10].\n\nKey note: There may be confusion with the true therapeutic target Succinate dehydrogenase complex iron sulfur subunit B (SDHB), but SDHB pseudogene 1 (SDHBP1) is not a valid or actionable drug target. If you are seeking data on the authentic disease-associated enzyme, refer to SDHB, not SDHBP1[1][7][10].

Other names

SDHBP1SDHB pseudogene 1