Sebaceous gland

The sebaceous gland is a small, holocrine, lipid-producing organ located in the dermis and typically associated with hair follicles as part of the pilosebaceous unit[3][5][7][9]. Its primary function is the production and secretion of sebum—an oily substance composed of triglycerides, wax esters, squalene, and metabolites—which moisturizes, lubricates, and provides a physical and antimicrobial barrier for the skin and hair[1][3][5][7]. Sebaceous glands are controlled hormonally, particularly by androgens which stimulate growth and lipid synthesis through nuclear androgen receptors[1]. They are involved in the skin's immune defense, wound healing, and act as sites of local steroid metabolism[1][4][8]. Dysfunction or excess production of sebum is central to acne and other dermatological disorders[8]. Sebaceous glands are not a molecular drug target (such as a receptor, enzyme, or transporter), but rather a multicellular skin appendage, and as such, the query is technically incorrect for lists of molecular targets[3][5][7][9].

Other names

Oil glandGlandula sebacea (Latin)Glandula sebacea holocrinaTarsal gland (in eyelids, also called meibomian gland)Areolar glandFordyce gland (modified forms)

Inhibition of sebaceous gland size and function (isotretinoin, retinoids), Blockade of androgen receptor signaling (antiandrogens), Suppression of inflammation (corticosteroids)