SEC14-like protein 3 (SEC14L3)

SEC14-like protein 3 (SEC14L3) is a multi-domain lipid transfer protein containing SEC14, GOLD, CARL-TRIO, and GTPase domains, and is part of a conserved protein family across eukaryotes responsible for controlling membrane identity and trafficking via lipid binding, exchange, and interaction with key signaling pathways[2][1][3]. SEC14L3 directly interacts with Wnt signaling components, such as Frizzled (Fz), Dishevelled (Dvl), and phospholipase C, to regulate calcium signaling and PLCδ activation in response to external cues like Wnt5a[1][3]. Both its lipid transfer and GTPase functions are essential for proper cellular signaling and developmental processes. SEC14-like proteins are implicated in cancer and neurodegenerative disease risk, likely due to their role in oxidative stress response and the maintenance of membrane integrity and signaling[2]. SEC14L3 may function as a tumor suppressor by mediating the transport of vitamin E (tocopherol) and other lipophilic substances, highlighting interconnected roles in lipid metabolism, cellular signaling, and homeostasis[2]. While no approved drugs currently target SEC14L3, its role in fundamental cellular processes makes it a potential therapeutic target pending further study[2][1][3].

Other names

SEC14L3SEC14-like protein 3Tocopherol-associated protein 2SEC14-like 3SEC14p-like protein TAP2

Not established for approved drugs. Possible mechanisms may involve regulation of membrane phospholipid composition, modulation of PLC signaling, or control of calcium flux via PLC activity