Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Sec61 Translocon (Sec61)
- Target
- Sec61
- Molecular classification
- Protein complex, Translocon, Ion channel
01
Overview
The Sec61 translocon is a highly conserved, heterotrimeric protein complex that forms the core of the protein-conducting channel in the endoplasmic reticulum (ER) membrane of eukaryotes and in the plasma membrane of prokaryotes. Its primary function is to mediate the translocation or integration of newly synthesized polypeptides into or across membranes, playing a central role in secretory and membrane protein biogenesis. Beyond its role in protein translocation, Sec61 also functions as an ER calcium leak channel, making it relevant to various disease states.
02
Mechanism of action
Modulation of protein translocation and/or calcium leak activity
03
Biological functions
Protein translocationProtein integrationCalcium leak channelER-associated degradation (ERAD)
04
Disease associations
Congenital neutropeniaPlasma cell deficiencyType II diabetesCancerER stressApoptosisIschemia-reperfusion injury
05
Safety considerations
Potential for off-target effects due to broad role in protein homeostasisModulation of calcium homeostasis may have unintended consequences
Beyond the preview
Go deeper on Sec61 Translocon (Sec61).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Sec61 Translocon (Sec61).