Secernin-1 (SCRN1)

Secernin-1 (SCRN1) is a soluble cytosolic protein, part of the secernin family, encoded by the *SCRN1* gene on human chromosome 7 [2][4]. It is best characterized as a regulator of exocytosis in mast cells and also exhibits protein binding and possible dipeptidase activity [2]. In the central nervous system, secernin-1 is a neuronal protein that specifically interacts with and accumulates in neurofibrillary tangles (NFTs) in Alzheimer's disease, Down syndrome with AD pathology, and PART, co-localizing with phosphorylated tau (pTau), but not with other tauopathies such as corticobasal degeneration, progressive supranuclear palsy, or Pick’s disease [1][3]. Recent work positions SCRN1 as a potentially unique marker of tau pathology in AD and a possible target for biomarker development, though its physiological function, especially in the brain, is still poorly characterized [1][3]. No drugs are currently known to target SCRN1 directly; the gene is also studied for roles in multiple cancers where it is frequently upregulated and associated with poor prognosis [2][1].

Other names

SCRN1SES1KIAA0193secernin 1secernin-1

Not established for therapies; secernin-1 itself interacts with phosphorylated tau, modulating tau pathology, but no drugs are known to target it directly