Secernin-2 (SCRN2)

Secernin-2 (SCRN2) is a member of the secernin family and the peptidase C69 family, although its enzymatic activity remains putative. It is a cytosolic protein involved in regulation of protein stability, notably acting as a tumor suppressor in triple-negative breast cancer (TNBC). SCRN2 suppresses cancer progression by stabilizing the histone methyltransferase KMT2C, promoting apoptotic pathways, and increasing sensitivity of TNBC cells to PARP inhibitors through enhancement of endogenous DNA damage. It is predominantly degraded via the chaperone-mediated autophagy-lysosome pathway, and its downregulation in TNBC correlates with poor patient prognosis. Emerging data also suggest roles in other cancer types, with limited evidence of involvement in neurodegenerative and respiratory diseases. SCRN2's molecular interactome includes proteins involved in actin dynamics and mRNA metabolism, reflecting pleiotropic cellular roles beyond cancer.

Other names

Secernin 2Ses2epididymis secretory sperm binding proteinSCRN2secernin-2

Sensitization to PARP inhibitors (i.e., SCRN2 overexpression enhances tumor cell response to Olaparib by inducing DNA damage and impairing DNA repair)