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Secondary Bile Acid Production (None)
- Target
- None
- Molecular classification
- Metabolic Process, Microbial Transformation
01
Overview
Secondary bile acid production is the microbial transformation of primary bile acids in the intestine, yielding secondary bile acids. This process is crucial for fat emulsification, enterohepatic circulation, and serves as signaling molecules regulating host metabolism and immune function. The main transformations involve deconjugation and 7α-dehydroxylation by gut microbiota, converting cholic acid to deoxycholic acid and chenodeoxycholic acid to lithocholic acid. Dysregulation of secondary bile acid production is implicated in various diseases, including metabolic disorders, liver diseases, and colon cancer.
- Other names
- Microbial Bile Acid TransformationIntestinal Bile Acid Modification
02
Mechanism of action
N/A
03
Biological functions
Bile acid metabolismLipid digestionGut microbiome modulationEnterohepatic circulationSignaling molecule productionImmune system modulation
04
Disease associations
Metabolic diseases (e.g., obesity, diabetes)Liver disorders (e.g., cholestasis, cirrhosis)Colon cancerInflammatory bowel disease (IBD)DyslipidemiaGallstone formation
05
Safety considerations
Overproduction of certain secondary bile acids (e.g., lithocholic acid) can be hepatotoxicDysbiosis leading to altered bile acid metabolism can contribute to disease
06
Biomarkers
Secondary bile acid profiles in serum or fecesGut microbiome composition
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