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Secreted factors from adipose-derived mesenchymal stromal cells (AD-MSC Secretome)

Target: AD-MSC Secretome
Molecular classification: Growth Factors, Cytokines, Chemokines, Extracellular Vesicles, Immunomodulatory Molecules

Overview

The secretome of adipose-derived mesenchymal stromal cells (AD-MSCs) comprises a diverse array of soluble factors and extracellular vesicles, including growth factors (VEGF, TGF-β1, IGF-1, HGF, bFGF), cytokines (IL-6, IL-8, IL-10, TNFα, IFNγ), chemokines, and immunomodulatory molecules (IDO, PGE2). These factors mediate angiogenesis, immunomodulation, tissue regeneration, and anti-fibrotic effects. Extracellular vesicles, particularly exosomes, play a significant role in modulating recipient cell behavior at the molecular level. AD-MSCs are being widely explored for cell therapies in inflammatory diseases, metabolic disorders, cardiovascular repair, wound healing, and neuroregeneration.

Other names: Adipose-derived stem cell secretomeAD-MSC conditioned mediumASC secretome

Mechanism of action

Paracrine signaling; modulation of recipient cell behavior via secreted factors and extracellular vesicles.

Biological functions

AngiogenesisImmunomodulationTissue RegenerationAnti-fibrotic EffectsCell signalingCell-cell communication

Disease associations

Inflammatory diseasesMetabolic disordersType II diabetes mellitusCardiovascular diseaseWound healingNeurodegenerative diseasesFibrosis

Safety considerations

Potential for altered functional properties in chronic inflammation or metabolic disease.Tumorigenicity of MSCsImmunogenicity of MSCs

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