Secreted frizzled-related protein 2 (SFRP2)

Secreted frizzled-related protein 2 (SFRP2) is a secreted glycoprotein belonging to the SFRP family, characterized by a cysteine-rich domain homologous to the Wnt-binding site of Frizzled receptors[2][4]. SFRP2 acts as a soluble modulator of the Wnt signaling pathway, capable of either inhibiting or potentiating Wnt signaling depending on tissue and context[1][2][3]. Biologically, SFRP2 regulates diverse processes including cell survival, apoptosis, proliferation, and differentiation, particularly by influencing β-catenin accumulation and downstream gene expression[1][2]. It plays roles in development, tissue repair, inflammation, and metabolic regulation, and is implicated in diseases such as cancer, cardiovascular disorders, fibrosis, and impaired wound healing[1][2][3][5]. SFRP2 promoter methylation functions as a biomarker for cancer detection and prognosis, while experimental recombinant SFRP2 has shown anti-tumor and anti-fibrotic effects in preclinical models[3][4]. The molecule’s context-dependent effects and broad expression raise therapeutic and safety considerations for targeted modulation[2][3].

Other names

FRP2SARP1FKSG12UNQ361/PRO697FRP-2sFRP-2SDF-5Secreted apoptosis-related protein 1testicular tissue protein Li 170

Modulation of Wnt/β-catenin signaling (inhibition or potentiation depending on context)[1][2][3] Interaction with Wnt family ligands and possibly Frizzled receptors[2] Regulation of β-catenin levels and downstream gene expression[1][2][3]