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Target intelligence / Profile preview
Secreted protein acidic and cysteine rich (SPARC)
- Target
- SPARC
- Molecular classification
- Other (matricellular protein), Extracellular matrix protein
01
Overview
Secreted protein acidic and cysteine rich (SPARC), also known as osteonectin or BM-40, is a matricellular glycoprotein broadly involved in modulating cell interactions with the extracellular matrix during tissue development, repair, and disease[1][2][4]. SPARC binds multiple extracellular components such as collagens and growth factors and influences cell adhesion, proliferation, and tissue remodeling; its expression is prominent in sites of tissue turnover and injury, and it is frequently dysregulated in cancer and fibrotic diseases[1].
- Other names
- OsteonectinBM-40Secreted protein acidic and rich in cysteine
02
Biological functions
Extracellular matrix regulationCell adhesion modulationRegulation of cell growthModulation of growth factor signalingTissue response to injuryCellular differentiation
03
Disease associations
CancerFibrosisCardiovascular diseaseTissue remodeling after injuryOther
04
Safety considerations
Possible involvement in tissue remodeling, fibrosis, and tumorigenicity; systemic inhibition or augmentation may affect normal tissue repair and regeneration
05
Biomarkers
SPARC expression can serve as a biomarker in cancer and fibrotic disorders
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