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Target intelligence / Profile preview
Secreted Protein Acidic and Rich in Cysteine (SPARC)
- Target
- SPARC
- Molecular classification
- Matricellular glycoprotein
01
Overview
SPARC is a multifunctional matricellular glycoprotein involved in various biological processes, including cell-matrix interactions, cell proliferation, growth factor modulation, and extracellular matrix organization. It plays a role in wound healing, embryogenesis, cancer progression, obesity, and aging. Dysregulation of SPARC is implicated in cancer, fibrosis, metabolic diseases, and ocular physiology.
- Other names
- OsteonectinBM-4043K protein
02
Biological functions
Regulation of cell-matrix interactionsInhibition of cellular proliferationModulation of growth factorsExtracellular matrix organizationTissue repair/regenerationCell renewal/growthBone mass maintenance/osteoblast maturationAngiogenesis regulationGlucose/lipid metabolism regulationAdipose tissue function/modulation
03
Disease associations
CancerFibrosisMetabolic diseasesOcular diseases
04
Biomarkers
Cancer progression/metastasisFibrosisWound healingEmbryogenesisObesity-related remodelingAging-associated changes
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