Secretin receptor family (class B G protein-coupled receptor family)

The **Secretin receptor family** (class B G protein-coupled receptor family) consists of structurally related cell surface receptors that respond primarily to peptide hormones of the glucagon hormone family, including secretin, glucagon, glucagon-like peptide 1, vasoactive intestinal peptide, calcitonin, parathyroid hormone, and others[1][2][3]. Members share a seven transmembrane domain architecture with a large extracellular N-terminal domain crucial for peptide hormone binding[1][2][3]. These receptors are critical mediators of various physiological responses, such as glucose metabolism, insulin secretion, bone turnover, cardiovascular regulation, and stress response, acting via activation of adenylyl cyclase and the phosphatidyl-inositol-calcium pathway[1][2][3][5]. The family comprises defined subgroups (notably subfamily B1, which includes "classical" hormone receptors such as the GLP-1 receptor, glucagon receptor, secretin receptor, and parathyroid hormone receptor)[1][2]. Due to their strong involvement in metabolic, endocrine, and cardiovascular disorders, these receptors are major targets for numerous approved drugs[2][5]. **Note:** The name "Secretin receptor family" refers to a molecular receptor family—a group of related drug targets—not a single molecular entity. For structured data, it is preferable to reference specific family members (e.g., "Glucagon-like peptide 1 receptor") rather than the family as a whole[1][2][3][5].

Other names

Class B G protein-coupled receptorsSecretin-like receptor familyFamily B GPCRsFamily 2 GPCRs

Agonism or antagonism at peptide hormone receptors to modulate cAMP and phosphatidylinositol-calcium pathway signaling