Secretion associated Ras related GTPase 1A pseudogene 2 (SAR1AP2)

Secretion associated Ras related GTPase 1A pseudogene 2 (SAR1AP2) is a **pseudogene** in humans with gene ID 641312[3]. Pseudogenes are genomic DNA sequences similar to normal genes but non-functional; they are typically the result of gene duplication or retrotransposition events and often lack coding potential due to mutations, premature stop codons, or deletions. While once considered "junk DNA", some pseudogenes can regulate expression of related genes through various RNA-mediated mechanisms, such as serving as competing endogenous RNAs or generating small interfering RNAs, which modulate coding gene expression[1]. There is no evidence that SAR1AP2 produces a functional protein or acts as a therapeutic target, receptor, enzyme, transporter, or similar pharmacological entity. Its biological function, disease association, or involvement in drug interactions has not been established. **Key notes:** - SAR1AP2 is **not a therapeutic target** and is instead best classified as a noncoding genomic element (pseudogene). - Standard drug target resources and molecular function databases do **not contain evidence of functional protein product, interaction with drugs, or clinical biomarker status** for SAR1AP2. - It is important not to confuse this pseudogene with the functional **SAR1A** gene, which encodes a small GTPase involved in ER-to-Golgi vesicle transport and is part of the Ras superfamily[2], but SAR1AP2 is not the same and does not code for this protein. This entry is best treated as a **pseudogene reference** and not a classic biomedical target.

Other names

Em:AC026226.2SARA1P