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Target intelligence / Profile preview
Secretion-regulating guanine nucleotide exchange factor (SERGEF)
- Target
- SERGEF
- Molecular classification
- Other (Guanine nucleotide exchange factor)
01
Overview
Secretion-regulating guanine nucleotide exchange factor (SERGEF) is a protein-coding gene product that is believed to act as a guanyl-nucleotide exchange factor (GEF) involved in the negative regulation of protein secretion[1][7]. Its molecular function appears related to promoting the exchange of GDP for GTP on target GTPases, a common mechanism of regulating vesicular trafficking within the cell. It localizes to the cytosol and nucleoplasm and is expressed in multiple human tissues[7][9][10]. SERGEF has been reported as a biomarker for atherosclerosis, but there is limited evidence supporting its direct, actionable role as a therapeutic target or its involvement in major disease pathways. Interacting partners predicted in STRING include proteins involved in vesicular transport and protein translation[3].
- Other names
- SERGEFDELGEFGNEFRDelGEFGnefrDeafness locus-associated putative guanine nucleotide exchange factorGuanine nucleotide exchange factor-related protein
02
Biological functions
Negative regulation of protein secretionGuanyl-nucleotide exchange factor activityPotential involvement in vesicular trafficking or secretion processes
03
Disease associations
Biomarker of atherosclerosisOther (potential, minimal direct disease evidence)
04
Biomarkers
May be used as a biomarker for atherosclerosis
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