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Target intelligence / Profile preview
Secretoglobin family 1A member 1 (SCGB1A1)
- Target
- SCGB1A1
- Molecular classification
- Secretoglobin, Lipocalin
01
Overview
SCGB1A1 encodes a small, secreted, disulfide-linked dimeric protein, the founding member of the secretoglobin family. It is specifically expressed in club cells of the airway epithelium and plays multiple roles in lung physiology and immune regulation. It possesses anti-inflammatory properties and protects against epithelial damage.
- Other names
- Uteroglobin (UG, UGB)Club cell secretory protein (CCSP)Clara-cell 16 kD protein (CC16; also called CC10 in some species)BlastokininPolychlorinated biphenyl-binding protein (PCB-BP)Human club cell phospholipid-binding protein (hCCPBP)
02
Mechanism of action
Inhibition of phospholipase A2, modulation of cytokine release
03
Biological functions
ImmunomodulationAnti-inflammatoryPhospholipase A2 inhibitionEpithelial protectionLigand binding (phospholipids, PCBs, progesterone)
04
Disease associations
AsthmaSilicosisBronchiolitis obliteransLung inflammationSmall airway injury
05
Safety considerations
Potential for altered expression to contribute to disease susceptibility (e.g., asthma)
06
Interacting drugs
None specified in the text, but PCBs are mentioned as ligands
07
Biomarkers
Circulating SCGB1A1 levels (indicator of lung epithelial integrity/damage)
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