Secretoglobin family 1C member 2 (SCGB1C2)

Secretoglobin family 1C member 2 (SCGB1C2) is a small, secreted, alpha-helical, disulfide-linked dimeric protein found only in mammals, and is thought to function predominantly in extracellular fluids[1][6][3][7]. Members of the secretoglobin family, including SCGB1C2, have been implicated in modulating inflammation, tissue repair, and potentially tumorigenesis, although the specific physiological actions and disease associations of SCGB1C2 remain poorly understood and require further study[2][6]. Its structure is homologous to other secretoglobins, featuring a dimer with a hydrophobic cavity formed at the interface, capable of binding small ligands, but its individual ligands and functional pathways have not been fully mapped[6]. SCGB1C2 is associated with inflammatory spondylopathy, reflecting a possible modulatory role in inflammation, and is mainly studied in the context of gene expression and knockout mouse phenotype models[1][5]. No drugs or therapeutic applications are currently linked to SCGB1C2[5].

Other names

SCGB1C2Secretoglobin family 1C member 2SCGB1C1Secretoglobin RYD5Secretoglobin family 1C member 1Secretoglobin, family 1C, member 1-like