Secretoglobin family 2A member 1 (SCGB2A1)

Secretoglobin family 2A member 1 (SCGB2A1), commonly known as mammaglobin-B, is a small secreted protein encoded by the SCGB2A1 gene on chromosome 11. Highly expressed in specific glandular tissues such as breast, uterus, and prostate, SCGB2A1 may bind androgens and steroid hormones, suggesting a role in hormonal regulation. Its expression is upregulated in various cancers, including ovarian, endometrial, and breast tumors, making it a potential antigen for immunotherapy and a candidate biomarker for cancer prognosis and detection. While its precise biological function remains incompletely understood, evidence supports roles in steroid hormone modulation, cell proliferation, and lipid metabolism. SCGB2A1 interacts with chemotherapeutic agents like estramustine and participates in tumor immune responses via cytotoxic T lymphocyte recognition[1][2][3][4][5][6].

Other names

Mammaglobin-BLIPHCMGB2UGB3LPNCLPHCLacryglobinLipophilin-CMammaglobin-2

Immunotherapy target: SCGB2A1-expressing tumor cells can be lysed by cytotoxic T lymphocytes in ovarian cancer[5]; Possible modulation of steroid hormone signaling (indirectly influences androgen/estrogen pathways)[2][3]