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Secretory blood group 1, pseudogene (SEC1P)

Target: SEC1P
Molecular classification: Other (pseudogene, glycosyltransferase-related pseudogene)

Overview

Secretory blood group 1, pseudogene (SEC1P) in humans is a member of the \u03b11,2-fucosyltransferase gene family that also includes FUT1 and FUT2, genes responsible for the biosynthesis of H antigen, a precursor for ABO blood group antigens[3][4]. In most mammals, the *Sec1* gene has become a pseudogene, meaning it no longer encodes a functional enzyme[1][2][3][4]. In the rabbit and some other leporids, *Sec1* retains partial function and has undergone *neofunctionalization*, acquiring a potential immunological role in pathogen resistance, but in humans, SEC1P is non-functional[1][2][3]. Human variation in \u03b11,2-fucosylated glycan expression (which determines the "secretor" phenotype) is instead mediated by polymorphisms in the FUT2 gene[3]. Therefore, SEC1P is not a therapeutic target and does not have a known physiological, therapeutic, or disease role in humans.

Other names: SEC1Sec1psecretory blood group 1

Mechanism of action

null (no drug mechanism due to lack of functional protein product.)

Biological functions

null (not functional in humans; in other mammals, *Sec1* homologs may have low or no enzymatic activity and can act as a dominant-negative variant impacting glycan diversity[1][3]. In humans, SEC1P is not functionally active[2][3].)

Disease associations

null (not directly implicated in diseases; variability in human blood group secretor status is determined by other functional genes, mainly FUT2[2][3].)

Safety considerations

null (no known safety issues as it is a non-functional gene.)

Interacting drugs

null (not a functional protein in humans; no drugs target this pseudogene.)

Biomarkers

null (SEC1P is not used as a biomarker.)

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