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Target intelligence / Profile preview
Secretory Phospholipase A2 (sPLA2)
- Target
- sPLA2
- Molecular classification
- Enzyme, Phospholipase
01
Overview
Secretory phospholipase A2 (sPLA2) is an enzyme that catalyzes the hydrolysis of the sn-2 ester bond in glycerophospholipids, releasing free fatty acids and lysophospholipids. It plays a crucial role in various biological processes, including inflammation, host immunity, and lipid signaling. Dysregulation of sPLA2 is linked to inflammatory diseases.
- Other names
- sPLA₂PLA2PLA₂PLA2G1BPLA₂G1BPLA₂-I BPLA₂-IIAPLA2GIIA
02
Mechanism of action
Catalyzes hydrolysis at the sn-2 position of membrane phospholipids to generate free fatty acids (often arachidonic acid) and lysophospholipid products.
03
Biological functions
Host defenseInflammationLipid metabolismCell migrationApoptosis regulationReactive oxygen species generationCytotoxicity modulationProliferation/differentiation controlCoagulation pathways involvement
04
Disease associations
Inflammatory diseasesRheumatoid arthritisAtherosclerosisCancer
05
Safety considerations
Dysregulation or overexpression linked to inflammatory diseases due to excessive production of pro-inflammatory lipid mediators.
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