Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Secretory phospholipase A2 group IIA (sPLA2-IIA)
- Target
- sPLA2-IIA
- Molecular classification
- Enzyme, Phospholipase
01
Overview
Secretory phospholipase A2 group IIA (sPLA2-IIA) is a secreted enzyme that hydrolyzes phospholipids, playing roles in inflammation, host defense, and eicosanoid signaling. It is implicated in various diseases including cardiovascular disease, inflammatory conditions, and cancer. Varespladib is an example of an inhibitor, but clinical trials have shown limited therapeutic benefits.
- Other names
- PLA2G2AGroup IIA phospholipase A2sPLA₂‐IIA
02
Mechanism of action
Inhibition of sPLA2-IIA
03
Biological functions
Hydrolysis of membrane phospholipidsAntimicrobial defenseEicosanoid signalingInflammationMediator release
04
Disease associations
Cardiovascular diseaseInflammatory diseasesCancerInfection
05
Safety considerations
Lack of consistent clinical efficacy of inhibitorsPotential for off-target effects
06
Interacting drugs
Varespladib
07
Biomarkers
Elevated sPLA2-IIA levels
Beyond the preview
Go deeper on Secretory phospholipase A2 group IIA (sPLA2-IIA).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Secretory phospholipase A2 group IIA (sPLA2-IIA).