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Target intelligence / Profile preview
Secretory phospholipase A2 group IIA (sPLA2-IIA)
- Target
- sPLA2-IIA
- Molecular classification
- Enzyme, Phospholipase
01
Overview
Secretory phospholipase A2 group IIA (sPLA2-IIA) is a secreted enzyme that hydrolyzes phospholipids, playing roles in inflammation, host defense, and eicosanoid signaling. It is implicated in various diseases including cardiovascular disease, inflammatory conditions, and cancer. Varespladib is an example of an inhibitor, but clinical trials have shown limited therapeutic benefits.
- Other names
- PLA2G2AGroup IIA phospholipase A2sPLA₂‐IIA
02
Mechanism of action
Inhibition of sPLA2-IIA
03
Biological functions
Hydrolysis of membrane phospholipidsAntimicrobial defenseEicosanoid signalingInflammationMediator release
04
Disease associations
Cardiovascular diseaseInflammatory diseasesCancerInfection
05
Safety considerations
Lack of consistent clinical efficacy of inhibitorsPotential for off-target effects
06
Interacting drugs
Varespladib
07
Biomarkers
Elevated sPLA2-IIA levels
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