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Target intelligence / Profile preview
Secretory Phospholipase A2 Group V (sPLA2-V)
- Target
- sPLA2-V
- Molecular classification
- Enzyme, Secretory phospholipase A2 (sPLA2) family
01
Overview
Secretory Phospholipase A2 Group V (sPLA2-V) is an enzyme encoded by the PLA2G5 gene. It belongs to the sPLA2 family and catalyzes the hydrolysis of membrane glycerophospholipids, releasing free fatty acids and lysophospholipids. sPLA2-V plays a dual role, contributing to both pro-inflammatory lipid mediator production in cardiovascular disease and protective functions against certain infections through modulation of host cell membranes and immune cell function. It is expressed in smooth muscle cells, epithelial cells, and macrophages, and its activity is calcium-dependent. Varespladib is an inhibitor of sPLA2-V.
- Other names
- PLA2G5
02
Mechanism of action
Inhibition of sPLA2-V enzymatic activity, preventing the hydrolysis of glycerophospholipids.
03
Biological functions
Lipid mediator generationLipoprotein modificationInnate immunityHydrolysis of membrane glycerophospholipids
04
Disease associations
AtherosclerosisInflammationInfectionCardiovascular disease
05
Safety considerations
Dual role in inflammation and infection, requiring careful consideration of therapeutic context.
06
Interacting drugs
Varespladib
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