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Target intelligence / Profile preview
Secretory Phospholipase A2 Group X (sPLA2-X)
- Target
- sPLA2-X
- Molecular classification
- Enzyme, Secreted Phospholipase A2
01
Overview
Secretory PLA2 group X (sPLA2-X) is a member of the secreted phospholipase A2 family. It is a calcium-dependent enzyme that hydrolyzes phospholipids, preferentially targeting phosphatidylcholines and phosphatidylglycerols. sPLA2-X plays a critical role in inflammation and immunity by releasing arachidonic acid, a precursor for pro-inflammatory mediators. It also contributes to lipoprotein remodeling and is implicated in the pathogenesis of asthma, allergy, and atherosclerosis. Its expression and activity are regulated by inflammatory signals, making it a potential therapeutic target.
- Other names
- PLA2G10
02
Mechanism of action
Inhibition of sPLA2-X enzymatic activity, reducing downstream eicosanoid and leukotriene production
03
Biological functions
Hydrolysis of phospholipidsEicosanoid generationLipoprotein remodelingPAF degradationRegulation of inflammationImmune response modulation
04
Disease associations
AsthmaAllergyInflammationAtherosclerosisEosinophilic disorders
05
Interacting drugs
sPLA2-X inhibitors
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