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Segment polarity protein dishevelled homolog DVL-2 (DVL2)
- Target
- DVL2
- Molecular classification
- Other (Signal transduction adaptor/scaffold protein)
01
Overview
Segment polarity protein dishevelled homolog DVL-2 (DVL2) is a cytoplasmic signaling adaptor protein encoded by the DVL2 gene and a member of the dishevelled protein family[1][2]. DVL2 functions as a crucial mediator in both canonical (β-catenin-dependent) and non-canonical Wnt signaling pathways, acting downstream of Frizzled family receptors to transmit Wnt signals to intracellular effectors and regulate cell fate, polarity, and developmental processes[2][4][5]. DVL2 is implicated in tumorigenesis, particularly in cancers where Wnt signaling is aberrantly activated, and interacts with proteins such as Zinc finger protein 165, DAB2, and Arrestin beta 1[1][2].
- Other names
- Dishevelled-2DSH homolog 2dishevelled 2 (homologous to Drosophila dsh)dishevelleddsh homolog 2
02
Mechanism of action
Modulation of Wnt/β-catenin signaling (as part of mechanism when targeted in research); Disruption of protein-protein interactions in Wnt pathway (conceptual)
03
Biological functions
Signal transductionRegulation of Wnt signalingCell fate determinationCell polarityRegulation of frizzled protein internalization and degradation
04
Disease associations
CancerColitis-associated colorectal progressionBone sarcomaOther (potential role in developmental disorders and Wnt pathway diseases)
05
Safety considerations
Potential broad impacts on cell development and tissue homeostasis when targeting Wnt pathway componentsRisk of off-target effects due to central role in cell fate choices and proliferation
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