Segment polarity protein dishevelled homolog DVL-3 (DVL3)

Segment polarity protein dishevelled homolog DVL-3 (DVL3) is an intracellular phosphoprotein and a member of the dishevelled family, homologous to Drosophila dishevelled (dsh). DVL3 functions as a key scaffold/adaptor protein in the Wnt signaling pathway, regulating gene transcription, cell polarity, and cytoskeletal dynamics during embryonic development and adult tissue homeostasis. In humans, DVL3 is critically involved in the formation and maintenance of cell-cell junctions, planar cell polarity, and cytoskeletal organization. Mutations in DVL3 are causally linked to autosomal dominant Robinow syndrome, a developmental disorder affecting skeletal, facial, and organ development. Aberrant DVL3 and Wnt pathway activity are implicated in various cancers and tissue regeneration disorders. Experimental manipulation (such as gene knockdown or pharmacological intervention) of DVL3 results in disruption of actin and microtubule networks, tight junctions, and tissue architecture, highlighting both its therapeutic potential and safety concerns

Other names

Dishevelled-3KIAA0208DSH homolog 3DRS3dishevelled 3 (homologous to Drosophila dsh)dishevelled, dsh homolog 3segment polarity protein dishevelled homolog DVL-3

Disruption/modulation of Wnt signaling (by inhibiting DVL3 scaffold/adaptor function); Blocking cytoskeletal reorganization (e.g., adjudin summary: downregulates DVL3, disrupts actin and microtubule tracks in Sertoli cells, impeding cell junction and spermatogenesis); General: modulation of DVL3 disrupts planar cell polarity, cell proliferation, and cell junction integrity