Seizure protein 6 homolog (SEZ6)

Seizure protein 6 homolog (SEZ6) is a type I transmembrane protein predominantly expressed in the nervous system, where it is essential for the development and maintenance of neuronal architecture and synaptic connectivity[1][3][8]. SEZ6 acts as a trafficking factor for kainate receptor subunits (GluK2/3), influencing their surface localization and glycosylation, which in turn modulates kainate-evoked synaptic currents[1]. It is a major substrate of the protease BACE1, which cleaves SEZ6 to release a soluble form that may serve as a biomarker for BACE1 activity, particularly in the context of neurodegenerative diseases such as Alzheimer's[1][3][4]. Mutations or altered regulation of SEZ6 have been implicated in epilepsy, psychiatric disorders, and potentially other neurodevelopmental and neurodegenerative conditions[6][3]. While SEZ6 itself is not currently the direct target of approved drugs, its pathway involvement makes it relevant for disease research and as a pharmacodynamic biomarker[1][3][4].

Other names

Seizure-related 6 homologSeizure protein 6SEZ6

Modulates trafficking and glycosylation of kainate receptor subunits (GluK2/3); Substrate of BACE1 protease, which cleaves SEZ6 and affects its function