Seizure related 6 homolog like (SEZ6L)

Seizure related 6 homolog like (SEZ6L) is a single-transmembrane domain protein highly expressed in neurons and the hippocampus, with large extracellular regions comprising CUB and complement control protein (CCP/SCR) domains. SEZ6L is an exclusive substrate of BACE1, an Alzheimer’s disease-linked protease. BACE1-mediated cleavage of SEZ6L produces soluble fragments detectable in CSF, providing a direct readout of BACE1 activity. SEZ6L influences excitatory synapse development, dendritic spine density, and complement regulation by facilitating Factor I-mediated C3b cleavage and limiting C3b deposition via both classical and alternative pathways. SEZ6L has roles in neurological and neuropsychiatric diseases as well as cancer, with variants linked to epilepsy and protein overexpression/deletion associated with lung cancer. SEZ6L and its family members represent important molecules for understanding synaptic biology, immune regulation in the brain, and therapeutic targets in neurodegenerative disease and cancer[1][2][3].

Other names

Seizure 6-like proteinKIAA0927UNQ2542/PRO6094SEZ6L1Seizure related gene 6-like

BACE inhibitors block the cleavage and shedding of SEZ6L, affecting synaptic function and potentially contributing to therapeutic and adverse effects during Alzheimer's disease treatment[1].