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Target intelligence / Profile preview
Seizure-related homolog 6 protein (SEZ6)
- Target
- SEZ6
- Molecular classification
- Type I transmembrane glycoprotein
01
Overview
Seizure-related homolog 6 protein (SEZ6) is a type I transmembrane glycoprotein highly expressed in neurons. It plays critical roles in neuronal development, synaptic regulation, and complement system regulation. SEZ6 influences synapse numbers, dendritic morphology, neuronal connectivity, and learning/memory processes. It also regulates glycosylation and trafficking of kainate receptor subunits GluK2/GluK3. Furthermore, SEZ6 inhibits opsonization by classical/alternative complement pathways. It is linked to Alzheimer's disease, schizophrenia, autism spectrum disorders, and is overexpressed in small cell lung cancer, making it a target for antibody-drug conjugates.
- Other names
- Seizure related homolog
02
Mechanism of action
Antibody-drug conjugate targeting SEZ6 in SCLC
03
Biological functions
Neuronal developmentSynaptic regulationComplement system regulationKainate receptor traffickingCell adhesion
04
Disease associations
Alzheimer's diseaseSchizophreniaAutism spectrum disordersSmall cell lung cancer
05
Safety considerations
Potential for off-target effects in the CNS due to widespread neuronal expressionToxicity associated with antibody-drug conjugates
06
Interacting drugs
ABBV-706
07
Biomarkers
SEZ6 expression level in SCLC
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