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Target intelligence / Profile preview
Seizure-related homolog protein 6 (SEZ6)
- Target
- SEZ6
- Molecular classification
- Single-pass transmembrane protein
01
Overview
SEZ6 is a single-pass transmembrane protein predominantly expressed in the nervous system, playing critical roles in neuronal development, synaptic function, and membrane signaling. It acts as a trafficking factor for kainate receptor subunits GluK2/3, modulating their glycosylation and surface expression. Additionally, SEZ6 inhibits complement activation by facilitating Factor I-mediated cleavage of C3b/iC3b. It is implicated in neurodevelopmental disorders such as Alzheimer's disease and psychiatric conditions due to its role in synaptic maintenance.
- Other names
- Seizure protein 6 homolog
02
Mechanism of action
Modulation of kainate receptor surface expression and glycosylation; Inhibition of classical complement pathway
03
Biological functions
Neuronal developmentSynaptic functionMembrane signalingKainate receptor traffickingComplement regulation
04
Disease associations
Neurodevelopmental disordersAlzheimer's diseasePsychiatric conditions
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