Selectin E (SELE)

Selectin E, commonly known as E-selectin or CD62E, is a 115 kDa cell-surface glycoprotein expressed exclusively on endothelial cells following activation by pro-inflammatory cytokines such as TNF-alpha and IL-1 beta [1, 3]. It functions as a calcium-dependent cell adhesion molecule that mediates the initial 'rolling' and tethering of leukocytes along the vascular wall, a critical step in the inflammatory cascade and immune cell extravasation [1]. In pathological contexts, E-selectin is a major driver of vaso-occlusive crises in sickle cell disease and facilitates the metastasis of various solid tumors by allowing cancer cells to adhere to the endothelium [4, 5]. In hematologic malignancies like acute myeloid leukemia (AML), E-selectin in the bone marrow vascular niche binds to leukemic stem cells, providing them with a protective environment that confers resistance to chemotherapy [2]. Therapeutic targeting of E-selectin primarily utilizes glycomimetic small molecules, such as uproleselan, which disrupt these adhesive interactions to mobilize diseased cells and enhance the efficacy of co-administered treatments [2, 4]. Citations: [1] UniProt (P16581); [2] DeAngelo et al., Blood (2022); [3] NCBI Gene (SELE); [4] Telen et al., Blood (2015); [5] Natoli et al., Cancer Research (2016).

Other names

E-selectinCD62EEndothelial-leukocyte adhesion molecule 1ELAM-1LECAM2CD62 antigen-like family member E

Competitive inhibition of E-selectin binding to sialyl Lewis X (sLeX) carbohydrate ligands on leukocytes or tumor cells