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Target intelligence / Profile preview
Selectin-Mediated Cell Adhesion (N/A)
- Target
- N/A
- Molecular classification
- Cell adhesion molecules (CAMs), Lectins
01
Overview
Selectin-mediated cell adhesion is a critical process involving the interaction between selectins (E-, P-, and L-selectin) and their carbohydrate ligands, primarily PSGL-1, on leukocytes and endothelial cells. This interaction initiates leukocyte rolling and adhesion to the endothelium, which is essential for immune surveillance, inflammation, and also contributes to thrombosis and cancer metastasis. Targeting selectins or their ligands offers therapeutic potential for treating inflammatory diseases and preventing cancer spread.
- Other names
- Selectin adhesionLeukocyte rollingEndothelial cell adhesionSelectin-dependent leukocyte trafficking
02
Mechanism of action
Inhibition of selectin-ligand binding, blocking leukocyte rolling and adhesion to the endothelium.
03
Biological functions
Immune cell traffickingInflammationThrombosisCancer metastasisCell-cell interaction
04
Disease associations
Chronic inflammationRheumatoid arthritisCardiovascular diseaseThrombosisCancer metastasis
05
Safety considerations
Increased risk of infection (due to impaired immune cell trafficking)Potential for off-target effects (due to selectin's role in multiple biological processes)Bleeding risk (due to P-selectin's role in platelet aggregation)
06
Interacting drugs
Selectin inhibitors
2 more in the full profile.
07
Biomarkers
E-selectin levelsP-selectin levelsL-selectin levelsPSGL-1 expressionCirculating tumor cells (CTCs)
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