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Target intelligence / Profile preview
Selectin P (P-selectin)
- Target
- P-selectin
- Molecular classification
- Cell Adhesion Molecule (CAM), Type-1 transmembrane protein, Lectins
01
Overview
P-selectin is a type-1 transmembrane protein that functions as a cell adhesion molecule (CAM) on the surfaces of activated endothelial cells and platelets. It plays a crucial role in mediating the interaction between these cells and leukocytes, particularly during inflammation and hemostasis.
- Other names
- CD62PGranule Membrane Protein 140 (GMP-140)Platelet Activation-Dependent Granule to External Membrane Protein (PADGEM)
02
Mechanism of action
N/A
03
Biological functions
Cell adhesionLeukocyte rolling and tetheringPlatelet-leukocyte interactionsInflammationHemostasisImmune response
04
Disease associations
Thrombotic diseases (e.g., ischemic stroke)Inflammatory disordersCancer metastasis
05
Safety considerations
Potential for increased risk of bleeding or thrombosis depending on the specific targeting strategy.
06
Biomarkers
Elevated plasma levels of soluble P-selectin as a biomarker for thrombotic risk
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