Target intelligence / Profile preview

Selenium Supplementation

Molecular classification
Nutritional Supplement, Mineral Supplement, Antioxidant
01

Overview

Selenium supplementation refers to the use of dietary supplements containing selenium, an essential trace mineral required for various physiological functions, including antioxidant defense, immune function, and thyroid hormone metabolism. Common supplemental forms include selenomethionine, selenium-enriched yeast, sodium selenite, and sodium selenate. Supplementation is typically recommended when dietary intake is insufficient or deficiency risk exists, but should be used within recommended limits due to potential toxicity risks at higher doses. Most individuals meet their needs through diet alone unless specific risk factors exist.

Other names
SeleniumSelenomethionineSelenium-enriched yeastSodium seleniteSodium selenate
02

Mechanism of action

Selenium is incorporated into selenoproteins, which function as antioxidants, participate in thyroid hormone metabolism, and support immune function.

03

Biological functions

Antioxidant defenseDNA synthesisImmune system functionThyroid hormone metabolismReproductive healthCofactor for selenoproteins
04

Disease associations

Selenium deficiencyCompromised immunityThyroid disordersInfertilityKeshan diseaseKashin-Beck diseaseOxidative stress
05

Safety considerations

Selenosis (toxicity)Hair lossNail brittleness/lossGastrointestinal upsetNeurological symptomsDrug interactionsExceeding Tolerable Upper Intake Level (UL)
06

Interacting drugs

Antacids

4 more in the full profile.

07

Biomarkers

Serum selenium levelsGlutathione peroxidase activity

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