Selenium-binding protein 1 (SELENBP1)

Selenium-binding protein 1 (SELENBP1) is a highly conserved intracellular protein that covalently binds selenium and belongs to the selenium-binding protein family. It exhibits methanethiol oxidase activity, converting methanethiol—a gut bacteria-derived organosulfur compound—into products such as hydrogen peroxide and hydrogen sulfide, which participate in redox regulation and cell signaling. SELENBP1 is implicated in critical biological functions including redox balance, intracellular protein degradation, intra-Golgi protein transport, and cell differentiation and motility. It has gained attention for its tumor suppressor role, as downregulation in various cancers is associated with poor outcomes. Additionally, altered SELENBP1 levels serve as biomarkers for cancer prognosis, cardiac injury, and neurological trauma. Its exact physiological and pathological roles remain an active area of research, and there are no approved drugs directly targeting SELENBP1 as of 2024.

Other names

SBP1hSP56LPSBSBP56SP5656 kDa selenium-binding proteinLp56SELENBP1Selenbp2

Not applicable (no direct pharmacological inhibitors or activators established for SELENBP1 as of 2024)