Target intelligence / Profile preview

Selenium ion (Se²⁻, Se⁴⁺, Se⁶⁺ (depending on oxidation state; no single canonical abbreviation))

Target
Se²⁻, Se⁴⁺, Se⁶⁺ (depending on oxidation state; no single canonical abbreviation)
Molecular classification
Other (elemental ion), not a protein, enzyme, receptor, or transporter
01

Overview

Selenium ions refer to selenium in its various ionic states (primarily selenide Se²⁻, selenite SeO₃²⁻, and selenate SeO₄²⁻). Selenium is a nonmetal element (atomic number 34, symbol Se) that is essential for human health as a component of selenoproteins involved in antioxidant defense and thyroid hormone metabolism[1][2][5][6]. Selenium ions are never themselves therapeutic targets like receptors or enzymes, but are instead incorporated into biomolecules or administered as supplements to treat or prevent selenium deficiency. Selenium status is relevant in various diseases, with roles both as an essential micronutrient and a potential toxicant at higher concentrations[2][5][6].

Other names
Selenium(II) ionSelenium(IV) ionSelenium(VI) ionselenide ion (Se²⁻)selenite ion (SeO₃²⁻)selenate ion (SeO₄²⁻)selenium cationselenium anion
02

Mechanism of action

Incorporated in selenoproteins (e.g., glutathione peroxidase) through dietary uptake; functions as cofactor in redox and antioxidant activities

03

Biological functions

Essential trace elementredox cofactor in selenoproteinsantioxidant functionthyroid hormone metabolism
04

Disease associations

Deficiency states (Keshan disease, myxedematous endemic cretinism)excess (selenosis)implication in cancer risk modulationimmune functioncardiovascular disease
05

Safety considerations

Narrow therapeutic window: deficiency and toxicity (selenosis, garlic breath, gastrointestinal symptoms, neurological abnormalities) are major concernsrisk with inappropriate supplementation
06

Interacting drugs

Selenium supplements (sodium selenite, sodium selenate)

2 more in the full profile.

07

Biomarkers

Blood or plasma selenium levelsselenoprotein Pglutathione peroxidase activity

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